Combining Bayesian optimization and automation to simultaneously optimize reaction conditions and routes

O Schilter, DP Gutierrez, LM Folkmann… - Chemical …, 2024 - pubs.rsc.org
Reaching optimal reaction conditions is crucial to achieve high yields, minimal by-products,
and environmentally sustainable chemical reactions. With the recent rise of artificial …

Development of On‐DNA Thiophene Synthesis for DEL Construction

A Luo, N Duchemin, X Wang, H Zhou… - Chemistry–An Asian …, 2023 - Wiley Online Library
Thiophene and its substituted derivatives are a highly important class of heterocyclic
compounds, with noteworthy applications in pharmaceutical ingredients. In this study, we …

Co-operative halogen bonds and nonconventional sp-C—H⋯ O hydrogen bonds in 1: 1 cocrystals formed between diethynylpyridines and N-halosuccinimides

E Bosch, NP Bowling - Acta Crystallographica Section C: Structural …, 2022 - scripts.iucr.org
The rapid evaporation of 1: 1 solutions of diethynylpyridines and N-halosuccinimides, that
react together to form haloalkynes, led to the isolation of unreacted 1: 1 cocrystals of the two …

Facile Access to Triazole-Fused 3, 1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C–O Coupling

SS Tatevosyan, YN Kotovshchikov, GV Latyshev… - …, 2022 - thieme-connect.com
A convenient approach to assemble 1, 2, 3-triazole-fused 4H-3, 1-benzoxazines has been
developed. Diverse alcohol-tethered 5-iodotriazoles, readily accessible by a modified …

[HTML][HTML] Highly Efficient 1-Iodination of Terminal Alkynes Catalyzed by Inorganic or Organic Bases

Y Yang, J Zhang, F Wan, E Liu, H Zhang - Catalysts, 2024 - mdpi.com
1-Iodoalkynes are one type of the most reactive and the most practical intermediates in
organic synthesis. Here, some facile and efficient methods for the 1-iodination of terminal …

Iodination of Substituted Alkynes in the Presence of Cadmium (II) Acetate

HB Sargsyan, KV Balyan, HR Pogosyan… - …, 2024 - Wiley Online Library
A convenient and selective method for the preparation of substituted iodoalkynes,
iodoalkenes based on the interaction of propargylic compounds with iodine in the presence …

Iodination of Phenylacetylene and Some Transformations of the Resulting Iodo Derivatives

NG Hobosyan, KV Balyan, HR Pogosyan… - Russian Journal of …, 2024 - Springer
An efficient procedure has been proposed for the reaction of molecular iodine with
phenylacetylene in the presence of cadmium (II) acetate in DMSO at room temperature, and …

[图书][B] Explorations in Medium-Ring Ether Synthesis via Umpolung Heteroatom Activation: Total Synthesis, Methods Development, and Reagent Synthesis

B Hoblos - 2021 - search.proquest.com
The Heliannuols are a family of structurally diverse allelochemicals produced by the
common sunflower which hold potential as environmentally benign herbicides; however …