Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and
recycles damaged mitochondria and regulates the biogenesis of new, fully functional ones …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …

Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …

The concept of macroautophagy was established in 1963, soon after the discovery of
lysosomes in rat liver. Over the 50 years since, studies of liver autophagy have produced …

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two
organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional …

For a long time, lysosomes were considered merely to be cellular'incinerators' involved in
the degradation and recycling of cellular waste. However, now there is compelling evidence …

Host dependency factors that are required for influenza A virus infection may serve as
therapeutic targets as the virus is less likely to bypass them under drug-mediated selection …

The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular
processes, such as lysosomal biogenesis and autophagy. The subcellular localization and …