Cisplatin is one of the most potent antitumor agents known, displaying clinical activity
against a wide variety of solid tumors. Its cytotoxic mode of action is mediated by its …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Biochemical modulation is the manipulation of cellular biochemical pathways by chemical
agents to produce selective enhancement of the efficacy of an antitumor drug. 1 Since the …

Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …

Cisplatin-based treatment is the first line chemotherapy for several cancers including
ovarian cancer. The development of cisplatin resistance results in treatment failure, but the …

The platinum drugs represent a unique and important class of antitumor agents. The clinical
development of the neutral, square planar, coordination complex cis …

Although cisplatin, cis-diamminedichloroplatinum (II), has been successfully used in the
chemotherapy of cancer for more than 25 years, its biochemical mechanism of action is still …

Full activation of protein kinase B (PKB)/Akt requires phosphorylation on Thr-308 and Ser-
473 by 3-phosphoinositide-dependent kinase-1 (PDK1) and Ser-473 kinase (S473K) …

The impact of cisplatin on cancer chemotherapy cannot be denied. Over the past 20 years,
much effort has been dedicated to discover new platinum‐based anticancer agents that are …

Platinum‐based compounds are widely used as chemotherapeutics for the treatment of a
variety of cancers. The anticancer activity of cisplatin and other platinum drugs is believed to …