Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
SF Zhou - Xenobiotica, 2008 - Taylor & Francis
1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
CYP3A4*22: Promising Newly Identified CYP3A4 Variant Allele for Personalizing Pharmacotherapy
L Elens, T Van Gelder, DA Hesselink… - …, 2013 - Taylor & Francis
Many studies have attempted to explain the interindividual variability observed in drug
metabolism by assessing the impact of SNPs in genes implicated in drug absorption …
metabolism by assessing the impact of SNPs in genes implicated in drug absorption …
MDR1 genotype-related pharmacokinetics: fact or fiction?
T Sakaeda - Drug metabolism and pharmacokinetics, 2005 - jstage.jst.go.jp
Multidrug resistant transporter MDR1WP-glycoprotein, the gene product of MDR1, is a
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …
Factors affecting cytochrome P-450 3A activity in cancer patients
Purpose: The purpose is to identify the demographic, physiologic, and inheritable factors
that influence CYP3A activity in cancer patients Experimental Design: A total of 134 patients …
that influence CYP3A activity in cancer patients Experimental Design: A total of 134 patients …
Influence of CYP3A5 and ABCB1 gene polymorphisms and other factors on tacrolimus dosing in Caucasian liver and kidney transplant patients
A Provenzani, M Notarbartolo… - International …, 2011 - spandidos-publications.com
Tacrolimus is a substrate of cytochrome P4503A (CYP3A) enzymes as well as of the drug
transporter ABCB1. We have investigated the possible influence of CYP3A5 and ABCB1 …
transporter ABCB1. We have investigated the possible influence of CYP3A5 and ABCB1 …
Cancer treatment and pharmacogenetics of cytochrome P450 enzymes
RHN van Schaik - Investigational new drugs, 2005 - Springer
For the treatment of cancer, the window between drug toxicity and suboptimal therapy is
often narrow. Interindividual variation in drug metabolism therefore complicates therapy …
often narrow. Interindividual variation in drug metabolism therefore complicates therapy …
A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells
Y Yamamoto, A Banas, S Murata, M Ishikawa… - The FEBS …, 2008 - Wiley Online Library
The specific features of the plasticity of adult stem cells are largely unknown. Recently, we
demonstrated the hepatic differentiation of human adipose tissue‐derived mesenchymal …
demonstrated the hepatic differentiation of human adipose tissue‐derived mesenchymal …
[HTML][HTML] Analysis of CYP3A4 genetic polymorphisms in Han Chinese
Our study aimed to comprehensively investigate the genetic polymorphisms of CYP3A4 in
Han Chinese. We sequenced the gene regions of CYP3A4, including its promoter, exons …
Han Chinese. We sequenced the gene regions of CYP3A4, including its promoter, exons …
Frequencies and roles of CYP3A5, CYP3A4 and ABCB1 single nucleotide polymorphisms in Italian teenagers after kidney transplantation
S Turolo, AS Tirelli, M Ferraresso, L Ghio… - Pharmacological …, 2010 - Springer
The main genes involved in the pharmacokinetics of immunosuppressive drugs are those
encoding cytochrome P450 (CYP) family enzymes and multidrug resistance 1 (ABCB1). In …
encoding cytochrome P450 (CYP) family enzymes and multidrug resistance 1 (ABCB1). In …
Pharmacogenomics of CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4, CYP3A5 and MDR1 in Vietnam
Aim The aim of this study was to obtain pharmacogenetic data in a Vietnamese population
on genes coding for proteins involved in the elimination of drugs currently used for the …
on genes coding for proteins involved in the elimination of drugs currently used for the …