In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …

Clustered imprinted genes are regulated by differentially methylated imprinting control
regions (ICRs) that affect gene activity and repression in cis over a large region. Although a …

The predominant methodology for DNA methylation analysis relies on the chemical
deamination by sodium bisulfite of unmodified cytosine to uracil to permit the differential …

Imprinted genes play crucial roles in mammalian development and disruption of their
expression is associated with many human disorders including tumourigenesis; yet, the …

In the adult heart, a variety of stresses induce re-expression of a fetal gene program in
association with myocyte hypertrophy and heart failure. Here we show that histone …

Although the factors responsible for the recent increase in the prevalence of diabetes
worldwide are not entirely known, the morbidity associated with this disease results in …

The epigenetic events that occur during the development of the mammalian embryo are
essential for correct gene expression and cell-lineage determination. Imprinted genes are …

Imprinted genes display differential allelic expression in a manner that depends on the sex
of the transmitting parent. The degree of imprinting is often tissue-specific and/or …

The maternal and paternal genomes play different roles in mammalian brains as a result of
genomic imprinting, an epigenetic regulation leading to differential expression of the …

In mammals, most somatic cells contain two copies of each autosomal gene, one inherited
from each parent. When a gene is expressed, both parental alleles are usually transcribed …