Safe and efficient drugs to combat the current COVID-19 pandemic are urgently needed. In
this context, we have analyzed the anti-coronavirus potential of the natural product …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and is associated with
high mortality and morbidity. Currently, no effective medical treatment is available to improve …

Abstract HMGB1 (High-Mobility Group Box-1) is a nuclear protein that acts as an
architectural chromatin-binding factor involved in the maintenance of nucleosome structure …

Abstract High Mobility Group Box 1 protein was discovered as a nuclear protein, but it has
a⿿ second life⿿ outside the cell where it acts as a damage-associated molecular pattern …

Previous studies have indicated that macrophage phenotype diversity is involved in the
progression of renal fibrosis. However, the factors facilitating M1 or M2 phenotypes and the …

Identifying the molecular targets for the beneficial effects of active small-molecule
compounds simultaneously is an important and currently unmet challenge. In this study, we …

The intake of quercetin and its glycosides has been proven to effectively reduce the level of
high mobility group protein 1 (HMGB1) and the degree of inflammation, but the underlying …

Even though amphiphilic natural products have been widely employed in cosmetics, food,
and pesticide formulations, the development of a compound with stimuli-responsiveness is …

Abstract Ethnopharmacological relevance Si-Miao-Yong-An decoction (SMYAD) is a
traditional Chinese herbal formulation. SMYAD first appeared in the Eastern Han Dynasty …