Glatiramer acetate immunomodulation: evidence of neuroprotection and cognitive preservation

A Kasindi, DT Fuchs, Y Koronyo, A Rentsendorj… - Cells, 2022 - mdpi.com
Novel, neuroprotective uses of Copaxone (generic name: glatiramer acetate—GA) are being
examined, primarily in neurological conditions involving cognitive decline. GA is a well …

Peptide hormones and lipopeptides: from self‐assembly to therapeutic applications

JA Hutchinson, S Burholt… - Journal of Peptide …, 2017 - Wiley Online Library
This review describes the properties and activities of lipopeptides and peptide hormones
and how the lipidation of peptide hormones could potentially produce therapeutic agents …

What animal models can tell us about long-term cognitive dysfunction following sepsis: a systematic review

FF Savi, A de Oliveira, GF de Medeiros… - Neuroscience & …, 2021 - Elsevier
Survivors of sepsis often develop long-term cognitive impairments. This review aimed at
exploring the results of the behavioral tools and tests which have been used to evaluate …

Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer's disease

M Dey, RK Singh - Toxicology Mechanisms and Methods, 2022 - Taylor & Francis
Aluminum is an environmentally abundant potential neurotoxic agent that may result in
oxidative damage to a range of cellular biomarkers. The potential sources of aluminum …

Release of interleukin-10 and neurotrophic factors in the choroid plexus: possible inductors of neurogenesis following copolymer-1 immunization after cerebral …

Y Cruz, EE García, JV Gálvez… - Neural regeneration …, 2018 - journals.lww.com
Abstract Copolymer-1 (Cop-1) is a peptide with immunomodulatory properties, approved by
the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop …

Propofol inhibits neuroinflammation and metabolic reprogramming in microglia in vitro and in vivo

S Guan, L Sun, X Wang, X Huang, T Luo - Frontiers in Pharmacology, 2023 - frontiersin.org
Microglial activation-induced neuroinflammation is closely related to the development of
sepsis-associated encephalopathy. Accumulating evidence suggests that changes in the …

Targets and mechanisms in prevention of Parkinson's disease through immunomodulatory treatments

M von Euler Chelpin… - Scandinavian Journal of …, 2017 - Wiley Online Library
Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world; however, there is no cure for it. Current treatments only relieve some of the symptoms …

Glatiramer acetate attenuates depressive/anxiety-like behaviors and cognitive deficits induced by post-weaning social isolation in male mice

SA Salihu, H Ghafari, M Ahmadimanesh… - …, 2021 - Springer
Rationale Major depressive disorder (MDD) is a debilitating disorder with adverse effects on
mood, memory, and quality of life. Objectives In this study, the antidepressant potential of …

[HTML][HTML] Interplay Between the Immune and Nervous Cognitive Systems in Homeostasis and in Malaria

LP de Sousa, P Rosa-Gonçalves… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
The immune and nervous systems can be thought of as cognitive and plastic systems, since
they are both involved in cognition/recognition processes and can be architecturally and …

Chronic N-acetylcysteine treatment alleviates acute lipopolysaccharide-induced working memory deficit through upregulating caveolin-1 and synaptophysin in mice

X Shen, Y Sun, M Wang, H Shu, LJ Zhu, PY Yan… - …, 2018 - Springer
Rationale Working memory (WM) is a dynamic encoding process and an active
representation of information over a short time. The ability to guide forthcoming behavior …