Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
Role of lipid-based and polymer-based non-viral vectors in nucleic acid delivery for next-generation gene therapy
The field of gene therapy has experienced an insurgence of attention for its widespread
ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA …
ability to regulate gene expression by targeting genomic DNA, messenger RNA, microRNA …
Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
highlighted the need for vaccines that not only prevent disease but also prevent …
highlighted the need for vaccines that not only prevent disease but also prevent …
Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination
An inhalable platform for messenger RNA (mRNA) therapeutics would enable minimally
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …
A Biodegradable Iridium (III) Coordination Polymer for Enhanced Two‐Photon Photodynamic Therapy Using an Apoptosis–Ferroptosis Hybrid Pathway
The clinical application of photodynamic therapy is hindered by the high glutathione
concentration, poor cancer‐targeting properties, poor drug loading into delivery systems …
concentration, poor cancer‐targeting properties, poor drug loading into delivery systems …
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance
In patients with glioblastoma, resistance to the chemotherapeutic temozolomide (TMZ) limits
any survival benefits conferred by the drug. Here we show that the convection-enhanced …
any survival benefits conferred by the drug. Here we show that the convection-enhanced …
Polymeric vehicles for nucleic acid delivery
AS Piotrowski-Daspit, AC Kauffman… - Advanced drug delivery …, 2020 - Elsevier
Polymeric vehicles are versatile tools for therapeutic gene delivery. Many polymers—when
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …
Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles
E Xu, WM Saltzman, AS Piotrowski-Daspit - Journal of Controlled Release, 2021 - Elsevier
Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
Biodegradable polymers for gene delivery
TJ Thomas, HA Tajmir-Riahi, CKS Pillai - Molecules, 2019 - mdpi.com
The cellular transport process of DNA is hampered by cell membrane barriers, and hence, a
delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a …
delivery vehicle is essential for realizing the potential benefits of gene therapy to combat a …
Poly (amino ester) s as an emerging synthetic biodegradable polymer platform: Recent developments and future trends
Poly (amino ester) s (PAEs) refer to a class of synthetic polymers characterized by repeating
units in the backbone having tertiary amines and ester bonds, and bringing together the …
units in the backbone having tertiary amines and ester bonds, and bringing together the …