Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic
steatohepatitis (NASH), represent a growing worldwide epidemic and a high unmet medical …

Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

The DNA-dependent protein kinase (DNA-PK) plays an instrumental role in the overall
survival and proliferation of cells. As a member of the phosphatidylinositol 3-kinase-related …

Liver cancer is a global health challenge, causing a significant social-economic burden.
Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer, which is …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel housekeeper of
hepatic mitochondrial homeostasis outside the DNA repair process. In this study, DNA-PKcs …

Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …

DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …

Maintenance of genomic stability is a critical determinant of cell survival and relies on the
coordinated action of the DNA damage response (DDR), which orchestrates a network of …