Neuropathic pain is caused by a lesion or disease of the somatosensory system, including
peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7–10% of the …

Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

Conditioned pain modulation (CPM) is a centrally processed measure of the net effect of the
descending pain pathway. This comprises both the facilitatory as well as the inhibitory effect …

Descending controls, comprising pathways that originate in midbrain and brainstem regions
and project onto the spinal cord, have long been recognised as key links in the multiple …

Supraspinal brain regions modify nociceptive signals in response to various stressors
including stimuli that elevate pain thresholds. The medulla oblongata has previously been …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Background The efficiency of descending pain modulation, commonly assessed with the
conditioned pain modulation procedure, is diminished in patients with chronic pain. The …

Sensory modulation disorder (SMD) affects sensory processing across single or multiple
sensory systems. The sensory over-responsivity (SOR) subtype of SMD is manifested …

Descending controls link higher processing of noxious signals to modulation of spinal cord
responses to their noxious inputs. It has become possible to study one key inhibitory system …