The cellular and functional complexity of thermogenic fat
P Cohen, S Kajimura - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …
in the form of heat. These thermogenic fat cells were originally considered to function solely …
The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists
G Bendotti, L Montefusco, ME Lunati, V Usuelli… - Pharmacological …, 2022 - Elsevier
In the last few years, a great interest has emerged in investigating the pleiotropic effects of
Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs). While GLP-1RAs ability to lower …
Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs). While GLP-1RAs ability to lower …
Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice
The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy
metabolism, glucose tolerance, immune system maturation and function in humans …
metabolism, glucose tolerance, immune system maturation and function in humans …
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
Immune cells residing in white adipose tissue have been highlighted as important factors
contributing to the pathogenesis of metabolic diseases, but the molecular regulators that …
contributing to the pathogenesis of metabolic diseases, but the molecular regulators that …
Mechanisms of action and therapeutic application of glucagon-like peptide-1
DJ Drucker - Cell metabolism, 2018 - cell.com
Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-
related glycemic excursions through augmentation of insulin and inhibition of glucagon …
related glycemic excursions through augmentation of insulin and inhibition of glucagon …
Glucagon-like peptide-1 receptor-based therapeutics for metabolic liver disease
JM Yabut, DJ Drucker - Endocrine Reviews, 2023 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) controls islet hormone secretion, gut motility, and
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …
Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation
BA McLean, CK Wong, JE Campbell… - Endocrine …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …
Immune and non-immune functions of adipose tissue leukocytes
Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …
Much of the work into understanding the role of immune cells in adipose tissue has been in …
Tissue-specific functions of invariant natural killer T cells
CM Crosby, M Kronenberg - Nature Reviews Immunology, 2018 - nature.com
Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis
AC Kohlgruber, ST Gal-Oz, NM LaMarche… - Nature …, 2018 - nature.com
Abstract γδ T cells are situated at barrier sites and guard the body from infection and
damage. However, little is known about their roles outside of host defense in nonbarrier …
damage. However, little is known about their roles outside of host defense in nonbarrier …