The cellular and functional complexity of thermogenic fat

P Cohen, S Kajimura - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists

G Bendotti, L Montefusco, ME Lunati, V Usuelli… - Pharmacological …, 2022 - Elsevier
In the last few years, a great interest has emerged in investigating the pleiotropic effects of
Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs). While GLP-1RAs ability to lower …

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

HS Yoon, CH Cho, MS Yun, SJ Jang, HJ You… - Nature …, 2021 - nature.com
The gut microbiota, which includes Akkermansia muciniphila, is known to modulate energy
metabolism, glucose tolerance, immune system maturation and function in humans …

Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

DA Jaitin, L Adlung, CA Thaiss, A Weiner, B Li… - Cell, 2019 - cell.com
Immune cells residing in white adipose tissue have been highlighted as important factors
contributing to the pathogenesis of metabolic diseases, but the molecular regulators that …

Mechanisms of action and therapeutic application of glucagon-like peptide-1

DJ Drucker - Cell metabolism, 2018 - cell.com
Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-
related glycemic excursions through augmentation of insulin and inhibition of glucagon …

Glucagon-like peptide-1 receptor-based therapeutics for metabolic liver disease

JM Yabut, DJ Drucker - Endocrine Reviews, 2023 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) controls islet hormone secretion, gut motility, and
body weight, supporting development of GLP-1 receptor agonists (GLP-1RA) for the …

Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation

BA McLean, CK Wong, JE Campbell… - Endocrine …, 2021 - academic.oup.com
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …

Immune and non-immune functions of adipose tissue leukocytes

WV Trim, L Lynch - Nature Reviews Immunology, 2022 - nature.com
Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence.
Much of the work into understanding the role of immune cells in adipose tissue has been in …

Tissue-specific functions of invariant natural killer T cells

CM Crosby, M Kronenberg - Nature Reviews Immunology, 2018 - nature.com
Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

AC Kohlgruber, ST Gal-Oz, NM LaMarche… - Nature …, 2018 - nature.com
Abstract γδ T cells are situated at barrier sites and guard the body from infection and
damage. However, little is known about their roles outside of host defense in nonbarrier …