[HTML][HTML] Tissue-Specific Regulation of CFTR Gene Expression
C Blotas, C Férec, S Moisan - International Journal of Molecular Sciences, 2023 - mdpi.com
More than 2000 variations are described within the CFTR (Cystic Fibrosis Transmembrane
Regulator) gene and related to large clinical issues from cystic fibrosis to mono-organ …
Regulator) gene and related to large clinical issues from cystic fibrosis to mono-organ …
Sodium butyrate epigenetically modulates high‐fat diet‐induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome …
TM Henagan, B Stefanska, Z Fang… - British journal of …, 2015 - Wiley Online Library
Background and Purpose Sodium butyrate (NaB), an epigenetic modifier, is effective in
promoting insulin sensitivity. The specific genomic loci and mechanisms underlying …
promoting insulin sensitivity. The specific genomic loci and mechanisms underlying …
Transcription factors and miRNAs that regulate fetal to adult CFTR expression change are new targets for cystic fibrosis
V Viart, A Bergougnoux, J Bonini… - European …, 2015 - Eur Respiratory Soc
The CFTR gene displays a tightly regulated tissue-specific and temporal expression.
Mutations in this gene cause cystic fibrosis (CF). In this study we wanted to identify trans …
Mutations in this gene cause cystic fibrosis (CF). In this study we wanted to identify trans …
[HTML][HTML] Chromatin Dynamics in the Regulation of CFTR Expression
The contribution of chromatin dynamics to the regulation of human disease-associated loci
such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the …
such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the …
[HTML][HTML] Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model
C Bednarski, K Tomczak, B Vom Hövel, WM Weber… - PloS one, 2016 - journals.plos.org
In vitro disease models have enabled insights into the pathophysiology of human disease as
well as the functional evaluation of new therapies, such as novel genome engineering …
well as the functional evaluation of new therapies, such as novel genome engineering …
A transcription factor network represses CFTR gene expression in airway epithelial cells
MJ Mutolo, SH Leir, SL Fossum, JA Browne… - Biochemical …, 2018 - portlandpress.com
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
the inherited disorder cystic fibrosis (CF). Lung disease is the major cause of CF morbidity …
the inherited disorder cystic fibrosis (CF). Lung disease is the major cause of CF morbidity …
Chromatin remodeling mediated by the FOXA1/A2 transcription factors activates CFTR expression in intestinal epithelial cells
The forkhead box A transcription factors, FOXA1 and FOXA2, function as pioneer factors to
open condensed chromatin and facilitate binding of other proteins. We showed previously …
open condensed chromatin and facilitate binding of other proteins. We showed previously …
Immune Mediators Regulate CFTR Expression through a Bifunctional Airway-Selective Enhancer
An airway-selective DNase-hypersensitive site (DHS) at kb− 35 (DHS-35kb) 5′ to the cystic
fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell …
fibrosis transmembrane conductance regulator (CFTR) gene is evident in many lung cell …
[HTML][HTML] Glucocorticoids distinctively modulate the CFTR channel with possible implications in lung development and transition into extrauterine life
M Laube, M Bossmann, UH Thome - PLoS One, 2015 - journals.plos.org
During fetal development, the lung is filled with fluid that is secreted by an active Cl-transport
promoting lung growth. The basolateral Na+, K+, 2Cl-cotransporter (NKCC1) participates in …
promoting lung growth. The basolateral Na+, K+, 2Cl-cotransporter (NKCC1) participates in …
[HTML][HTML] CFTR Cooperative Cis-Regulatory Elements in Intestinal Cells
About 8% of the human genome is covered with candidate cis-regulatory elements (cCREs).
Disruptions of CREs, described as “cis-ruptions” have been identified as being involved in …
Disruptions of CREs, described as “cis-ruptions” have been identified as being involved in …