Disrupting tumour blood vessels
GM Tozer, C Kanthou, BC Baguley - Nature Reviews Cancer, 2005 - nature.com
Low-molecular-weight vascular-disrupting agents (VDAs) cause a pronounced shutdown in
blood flow to solid tumours, resulting in extensive tumour-cell necrosis, while they leave the …
blood flow to solid tumours, resulting in extensive tumour-cell necrosis, while they leave the …
Dynamic contrast enhanced magnetic resonance imaging in oncology: theory, data acquisition, analysis, and examples
TE Yankeelov, JC Gore - Current Medical Imaging, 2007 - ingentaconnect.com
Dynamic contrast enhanced MRI (DCE-MRI) enables the quantitative assessment of tumor
status and has found application in both pre-clinical tumor models as well as clinical …
status and has found application in both pre-clinical tumor models as well as clinical …
[HTML][HTML] DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
JPB O'Connor, A Jackson, GJM Parker… - British journal of …, 2007 - nature.com
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently
used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds …
used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds …
Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging
A Jackson, JPB O'Connor, GJM Parker… - Clinical Cancer Research, 2007 - AACR
This article reviews the application of dynamic contrast-enhanced magnetic resonance
imaging in both clinical studies and early-phase trials of angiogenesis inhibitors. Emphasis …
imaging in both clinical studies and early-phase trials of angiogenesis inhibitors. Emphasis …
Vascular disrupting agents
JW Lippert III - Bioorganic & medicinal chemistry, 2007 - Elsevier
A clear definition for vascular targeting agents (VTAs) and vascular disrupting agents (VDAs)
has separated the two as distinct methods of cancer treatment. VDAs differ from VTAs …
has separated the two as distinct methods of cancer treatment. VDAs differ from VTAs …
Angiogenesis and lung cancer: prognostic and therapeutic implications
Lung cancer is the most common cause of cancer death worldwide, with most patients dying
with metastatic disease. The prognosis for the majority of patients remains poor. It is evident …
with metastatic disease. The prognosis for the majority of patients remains poor. It is evident …
Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
MR Horsman, DW Siemann - Cancer research, 2006 - AACR
A functional vascular supply is critical for the continued growth and development of solid
tumors. It also plays a major role in metastatic spread of tumor cells. This importance has led …
tumors. It also plays a major role in metastatic spread of tumor cells. This importance has led …
Predicting benefit from anti-angiogenic agents in malignancy
AM Jubb, AJ Oates, S Holden, H Koeppen - Nature Reviews Cancer, 2006 - nature.com
A high probability of benefit is desirable to justify the choice of anti-angiogenic therapy from
an ever-expanding list of expensive new anticancer agents. However, biomarkers of …
an ever-expanding list of expensive new anticancer agents. However, biomarkers of …
Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis …
G Liu, HS Rugo, G Wilding, TM McShane… - Journal of clinical …, 2005 - ascopubs.org
Purpose Identifying suitable markers of biologic activity is important when assessing novel
compounds such as angiogenesis inhibitors to optimize the dose and schedule of therapy …
compounds such as angiogenesis inhibitors to optimize the dose and schedule of therapy …
Diffusion-weighted intravoxel incoherent motion imaging of renal tumors with histopathologic correlation
H Chandarana, SK Kang, S Wong… - Investigative …, 2012 - journals.lww.com
Purpose The aim of this study was to use intravoxel incoherent motion diffusion-weighted
imaging to discriminate subtypes of renal neoplasms and to assess agreement between …
imaging to discriminate subtypes of renal neoplasms and to assess agreement between …