Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges

LJ Millar, L Shi, A Hoerder-Suabedissen… - Frontiers in cellular …, 2017 - frontiersin.org
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

Autophagy in acute brain injury

L Galluzzi, JM Bravo-San Pedro, K Blomgren… - Nature Reviews …, 2016 - nature.com
Autophagy is an evolutionarily ancient mechanism that ensures the lysosomal degradation
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …

Animal models for neonatal brain injury induced by hypoxic ischemic conditions in rodents

N Hamdy, S Eide, HS Sun, ZP Feng - Experimental Neurology, 2020 - Elsevier
Neonatal hypoxia-ischemia and resulting encephalopathies are of significant concern.
Intrapartum asphyxia is a leading cause of neonatal death globally. Among surviving infants …

[HTML][HTML] Impact of perinatal hypoxia on the developing brain

M Piešová, M Mojmír - Physiological research, 2020 - ncbi.nlm.nih.gov
Perinatal hypoxia is still one of the greatest threats to the newborn child, even in developed
countries. However, there is a lack of works which summarize up-to-date information about …

The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior

LC Motta-Teixeira, AV Machado-Nils… - Hormones and …, 2018 - Elsevier
Maternal melatonin provides photoperiodic information to the fetus and thus influences the
regulation and timing of the offspring's internal rhythms and preparation for extra-uterine …

Heat stress induces autophagy in pig ovaries during follicular development

BJ Hale, CL Hager, JT Seibert, JT Selsby… - Biology of …, 2017 - academic.oup.com
Hyperthermia or heat stress (HS) occurs when heat dissipation mechanisms are
overwhelmed by external and internal heat production. Hyperthermia negatively affects …

Perinatal brain injury and inflammation: lessons from experimental murine models

A Leavy, EM Jimenez Mateos - Cells, 2020 - mdpi.com
Perinatal brain injury or neonatal encephalopathy (NE) is a state of disturbed neurological
function in neonates, caused by a number of different aetiologies. The most prominent cause …

Dexmedetomidine alleviates hypoxia‐induced synaptic loss and cognitive impairment via inhibition of microglial NOX2 activation in the hippocampus of neonatal rats

X Chen, D Chen, Q Li, S Wu, J Pan… - Oxidative Medicine …, 2021 - Wiley Online Library
Background. Perinatal hypoxia is a universal cause of death and neurological deficits in
neonates worldwide. Activation of microglial NADPH oxidase 2 (NOX2) leads to oxidative …

[HTML][HTML] Hippocampal metabolites in asthma and their implications for cognitive function

JL Kroll, AM Steele, AE Pinkham, C Choi, DA Khan… - NeuroImage: Clinical, 2018 - Elsevier
Emerging research indicates that individuals with asthma have an increased risk of cognitive
impairment, yet the associations of asthma with neural correlates of memory remain …

Current evidence on cell death in preterm brain injury in human and preclinical models

AC Truttmann, V Ginet, J Puyal - Frontiers in cell and developmental …, 2020 - frontiersin.org
Despite tremendous advances in neonatal intensive care over the past 20 years, prematurity
carries a high burden of neurological morbidity lasting lifelong. The term encephalopathy of …