Enhancing the safety of CAR-T cell therapy: Synthetic genetic switch for spatiotemporal control

L Lu, M Xie, B Yang, W Zhao, J Cao - Science Advances, 2024 - science.org
Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted
therapy for cancer that has demonstrated notable potential in clinical applications. However …

Mechanisms and strategies for safe chimeric antigen receptor T‐cell activity control

S Stock, AK Klüver, L Fertig… - … Journal of Cancer, 2023 - Wiley Online Library
The clinical application of chimeric antigen receptor (CAR) T‐cell therapy has rapidly
changed the treatment options for terminally ill patients with defined blood‐borne cancer …

Genetically encoded self-assembling protein nanoparticles for the targeted delivery in vitro and in vivo

AS Obozina, EN Komedchikova, OA Kolesnikova… - Pharmaceutics, 2023 - mdpi.com
Targeted nanoparticles of different origins are considered as new-generation diagnostic and
therapeutic tools. However, there are no targeted drug formulations within the composition of …

Internalization-responsive poly (lactic-co-glycolic acid) nanoparticles for image-guided photodynamic therapy against HER2-positive breast cancer

AS Sogomonyan, SM Deyev… - ACS Applied Nano …, 2023 - ACS Publications
Oncotheranostic nanoagents are powerful artificial tools that significantly outperform
traditional antitumor therapies. Among the wide variety of nanoagents, poly (lactic-co …

Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step …

VO Shipunova, EN Komedchikova, PA Kotelnikova… - Pharmaceutics, 2023 - mdpi.com
Therapy for aggressive metastatic breast cancer remains a great challenge for modern
biomedicine. Biocompatible polymer nanoparticles have been successfully used in clinic …

Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted …

EN Komedchikova, OA Kolesnikova, ED Tereshina… - Pharmaceutics, 2022 - mdpi.com
Nanoparticle-based chemotherapy is considered to be an effective approach to cancer
diagnostics and therapy in modern biomedicine. However, efficient tumor targeting remains …

From barriers to novel strategies: smarter CAR T therapy hits hard to tumors

MB Khawar, F Ge, A Afzal, H Sun - Frontiers in Immunology, 2023 - frontiersin.org
Chimeric antigen receptor (CAR) T cell therapy for solid tumors shows promise, but several
hurdles remain. Strategies to overcome barriers such as CAR T therapy-related toxicities …

Modular (universal) CAR-T platforms in vivo: a comprehensive systematic review

A Mohammad, A Yurina, T Simonyan… - Frontiers in …, 2024 - frontiersin.org
Background Modular (universal) CAR T-platforms were developed to combat the limitations
of traditional CAR-T therapy, allowing for multiple targeting of tumor-associated antigens …

Optimizing combination targeted immunotoxin therapy: Insights from HER2 and EpCAM expression profiles

AS Obozina, AA Pakhomov, AY Frolova… - Biochemical and …, 2024 - Elsevier
Molecular targeted cancer therapy is a rapidly developing field, driving progress toward
greater treatment efficacy. However, targeted monotherapy often fails due to the …

Nanomodified Switch Induced Precise and Moderate Activation of CAR‐T Cells for Solid Tumors

X Wang, F Meng, X Li, L Xue, A Chen, Y Qiu… - Advanced …, 2023 - Wiley Online Library
Chimeric antigen receptor (CAR)‐T cell therapy is a transformative treatment against
advanced malignancies. Unfortunately, once administrated in vivo, CAR‐T cells become out …