Medulloblastoma, the most common malignant paediatric brain tumour, is currently
diagnosed and stratified using a combination of clinical and demographic variables. Recent …

Recent efforts at stratifying medulloblastomas based on their molecular features have
revolutionized our understanding of this morbidity. Collective efforts by multiple independent …

Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of
morbidity and mortality in pediatric oncology. Current mechanisms for clinical …

Medulloblastoma is heterogeneous, being characterized by molecular subgroups that
demonstrate distinct gene expression profiles. Activation of the WNT or SHH signaling …

Purpose Medulloblastoma is a rare primary brain tumor in adults, whereas it constitutes the
most common malignant brain tumor in children. Integrated genomics approaches revealed …

Recent integrative genomic approaches have defined molecular subgroups of
medulloblastoma that are genetically and clinically distinct. Sonic hedgehog (Shh) …

Adult medulloblastomas are clinically and molecularly understudied due to their rarity. We
performed molecular grouping, targeted sequencing, and TERT promoter Sanger …

Background: Medulloblastoma is the most common malignant brain tumor in children,
currently treated uniformly based on histopathology and clinico-radiological risk stratification …

BACKGROUND: Medulloblastoma in adulthood is rare. Knowledge is limited, and the
efficacy and toxicity of chemotherapy–especially in nonmetastatic disease–is still elusive …

Medulloblastoma is the most common malignant childhood brain tumor and is associated
with a poor outcome. There is an urgent need to develop novel targeted therapeutic …