Recent development of gold (I) and gold (III) complexes as therapeutic agents for cancer diseases
Y Lu, X Ma, X Chang, Z Liang, L Lv, M Shan… - Chemical Society …, 2022 - pubs.rsc.org
Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …
are well established in the clinical application of cancer chemotherapy. However, the …
LNL-Carbazole Pincer Ligand: More than the Sum of Its Parts
G Kleinhans, AJ Karhu, H Boddaert, S Tanweer… - Chemical …, 2023 - ACS Publications
The utility of carbazole in photo-, electro-, and medicinal applications has ensured its
widespread use also as the backbone in tridentate pincer ligands. In this review, the aim is …
widespread use also as the backbone in tridentate pincer ligands. In this review, the aim is …
Current Developments of N-Heterocyclic Carbene Au(I)/Au(III) Complexes toward Cancer Treatment
A Tialiou, J Chin, BK Keppler, MR Reithofer - Biomedicines, 2022 - mdpi.com
Since their first discovery, N-heterocyclic carbenes have had a significant impact on
organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they …
organometallic chemistry. Due to their nature as strong σ-donor and π-acceptor ligands, they …
A New Class of Gold (I) NHC Complexes with Proapoptotic and Resensitizing Properties towards Multidrug Resistant Leukemia Cells Overexpressing BCL-2
F Bannwart, LF Richter, S Stifel, J Rueter… - Journal of Medicinal …, 2024 - ACS Publications
From previous studies, it is evident that metal–organic gold (I) complexes have
antiproliferative activities. The aim of this study is not only to find new anticancer agents but …
antiproliferative activities. The aim of this study is not only to find new anticancer agents but …
Gold (I) metallocyclophosphazenes with antibacterial potency and antitumor efficacy. Synergistic antibacterial action of a heterometallic gold and silver …
E Gascón, I Otal, S Maisanaba… - Dalton …, 2022 - pubs.rsc.org
One of the most important uses of phosphazenes today involves its biomedical applications.
They can also be employed as scaffolds for the design and construction of a variety of …
They can also be employed as scaffolds for the design and construction of a variety of …
Ionic mononuclear [Fe] and heterodinuclear [Fe, Ru] bis (diphenylphosphino) alkane complexes: Synthesis, spectroscopy, DFT structures, cytotoxicity, and …
M Odachowski, R Neven, G Perversi, D Romano… - Journal of Inorganic …, 2023 - Elsevier
Abstract Iron (II) and Ru (II) half-sandwich compounds encompass some promising pre-
clinical anticancer agents whose efficacy may be tuned by structural modification of the …
clinical anticancer agents whose efficacy may be tuned by structural modification of the …
Therapeutic potential of Ag (i)–, Au (i)–, and Au (iii)–NHC complexes of 3-pyridyl wingtip N-heterocyclic carbenes (NHCs) against lung cancer
Herein, we report the easy synthetic approaches, structural features, theoretical studies, and
extensive bioactivity of [Ag (1) 2][PF6](2),[Au (1) 2][PF6](3), and [Au (1) Cl3](4) compounds …
extensive bioactivity of [Ag (1) 2][PF6](2),[Au (1) 2][PF6](3), and [Au (1) Cl3](4) compounds …
On the Interaction of Gold (III) Complexes with Human Serum Albumin
IV Mironov, VY Kharlamova - Russian Journal of Inorganic Chemistry, 2023 - Springer
The interaction of gold (III) complexes (Au (bipy), Au (phen), and Au (dien-H) Cl+) with
human serum albumin (HSA) was studied in aqueous solutions (pH 7.4, C NaCl= 0.2 M, C …
human serum albumin (HSA) was studied in aqueous solutions (pH 7.4, C NaCl= 0.2 M, C …
S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells via mitochondrial dependent pathway induced by tricyclohexylphosphine gold (I) n …
AK Pian, CP Foong, R Abd Hamid - Life Sciences, 2022 - Elsevier
We have previously reported the inhibition of thioredoxin reductase (TrxR) and invasion by
tricyclohexylphosphine gold (I) n-mercaptobenzoate (n= 2, 3, 4) labeled as 1–3 towards …
tricyclohexylphosphine gold (I) n-mercaptobenzoate (n= 2, 3, 4) labeled as 1–3 towards …
Interaction of Au (iii) with amino acids: a vade mecum for medicinal chemistry and nanotechnology
Au (III) is highly reactive. At odds with its reduced counterpart, Au (I), it is hardly present in
structural databases. And yet, it is the starting reactant to form gold nanoclusters (AuNCs) …
structural databases. And yet, it is the starting reactant to form gold nanoclusters (AuNCs) …