[HTML][HTML] The emerging importance of lymphatics in health and disease: an NIH workshop report
The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …
[HTML][HTML] The pre-metastatic niche in lymph nodes: formation and characteristics
L Gillot, L Baudin, L Rouaud, F Kridelka… - Cellular and Molecular …, 2021 - Springer
Lymph node metastasis is a crucial prognostic parameter in many different types of cancers
and a gateway for further dissemination to distant organs. Prior to metastatic dissemination …
and a gateway for further dissemination to distant organs. Prior to metastatic dissemination …
[HTML][HTML] Communication, construction, and fluid control: lymphoid organ fibroblastic reticular cell and conduit networks
Fibroblastic reticular cells (FRCs) are a crucial part of the stromal cell infrastructure of
secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for …
secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for …
Imaging dendritic cell functions
B Bošnjak, KTH Do, R Förster… - Immunological …, 2022 - Wiley Online Library
Dendritic cells (DCs) are crucial for the appropriate initiation of adaptive immune responses.
During inflammation, DCs capture antigens, mature, and migrate to lymphoid tissues to …
During inflammation, DCs capture antigens, mature, and migrate to lymphoid tissues to …
[HTML][HTML] Protective fibroblastic niches in secondary lymphoid organs
A De Martin, Y Stanossek, NB Pikor… - Journal of Experimental …, 2024 - rupress.org
Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …
[HTML][HTML] Lymph node fibroblastic reticular cells preserve a tolerogenic niche in allograft transplantation through laminin α4
Lymph node (LN) fibroblastic reticular cells (FRCs) define LN niches and regulate
lymphocyte homeostasis through producing diverse extracellular matrix (ECM) components …
lymphocyte homeostasis through producing diverse extracellular matrix (ECM) components …
[HTML][HTML] Computational fluid dynamic modeling of the lymphatic system: a review of existing models and future directions
TD Jayathungage Don, S Safaei… - … and Modeling in …, 2024 - Springer
Historically, research into the lymphatic system has been overlooked due to both a lack of
knowledge and limited recognition of its importance. In the last decade however, lymphatic …
knowledge and limited recognition of its importance. In the last decade however, lymphatic …
Physiologically based pharmacokinetic modeling of 3 HIV drugs in combination and the role of lymphatic system after subcutaneous dosing. Part 2: model for the drug …
S Perazzolo, DD Shen, RJY Ho - Journal of pharmaceutical sciences, 2022 - Elsevier
We previously developed a mechanism-based pharmacokinetic (MBPK) model to
characterize the PK of a lymphocyte-targeted, long-acting 3 HIV drug-combination …
characterize the PK of a lymphocyte-targeted, long-acting 3 HIV drug-combination …
[HTML][HTML] Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of mesenteric lymph nodes
K Streich, M Smoczek, J Hegermann… - Journal of advanced …, 2020 - Elsevier
In obesity, increased dietary lipids are taken up and transported by the lymphatic systems
into the circulatory system. Increased fat accumulation results in impairments in the lymph …
into the circulatory system. Increased fat accumulation results in impairments in the lymph …
[HTML][HTML] Three-dimensional analyses of vascular network morphology in a murine lymph node by X-ray phase-contrast tomography with a 2D Talbot array
FL Schwarzenberg, P Schütz, JU Hammel… - Frontiers in …, 2022 - frontiersin.org
With growing molecular evidence for correlations between spatial arrangement of blood
vasculature and fundamental immunological functions, carried out in distinct compartments …
vasculature and fundamental immunological functions, carried out in distinct compartments …