Significance: Reactive oxygen species (ROS) are generated during mitochondrial oxidative
metabolism, and are tightly controlled through homeostatic mechanisms to maintain …

Thioredoxin (Trx) is a compact redox-regulatory protein that modulates cellular redox state
by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and a cofactor …

Background This study explores the repurposing of Auranofin (AF), an anti-rheumatic drug,
for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal …

Olaparib has been approved as a therapeutic option for metastatic pancreatic ductal
adenocarcinoma patients with BRCA1/2 mutations. However, a significant majority of …

Lung cancer is a highly prevalent malignant tumor worldwide, with high incidence and death
rates. Recently, there has been increasing recognition of the role of ferroptosis, a unique cell …

There is an urgent need to develop safer and more effective modalities for the treatment of a
wide range of pathologies due to the increasing rates of drug resistance, undesired side …

Background/Aim: Osteosarcoma (OS) is a rare malignant tumor with a poor survival rate. Our
previous study reported that auranofin (AUR), a thioredoxin reductase inhibitor, suppresses …

In this study, we investigated the formulation of stable solid dispersions to enhance the
bioavailability of olaparib (OLA), a therapeutic agent for ovarian cancer and breast cancer …

Elevated cellular oxidative stress is a common marker of cancer cell dysregulation caused
by malignant transformation. Thioredoxin reductase (TrxR, encoded by TXNRD) is a crucial …

非小细胞肺癌（ non-small cell lung cancer, NSCLC） 是全球发病率和死亡率较高的恶性肿瘤之
一。 铁死亡是铁依赖性活性氧（ reactive oxygen species, ROS） 异常堆积导致脂质过氧化而 …