The brain tumor microenvironment

NA Charles, EC Holland, R Gilbertson, R Glass… - Glia, 2012 - Wiley Online Library
High‐grade brain tumors are heterogeneous with respect to the composition of bona fide
tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas …

The brain tumor microenvironment

NA Charles, EC Holland, R Gilbertson, R Glass… - Glia, 2011 - Wiley Online Library
High‐grade brain tumors are heterogeneous with respect to the composition of bona fide
tumors cells and with respect to a range of intermingling parenchymal cells. Glioblastomas …

MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo

XX He, Y Chang, FY Meng, MY Wang, QH Xie, F Tang… - Oncogene, 2012 - nature.com
MicroRNAs (miRNAs) are believed to have fundamental roles in tumorigenesis and have
great potential for the diagnosis and treatment of cancer. However, the roles of miRNAs in …

LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer

L Luo, H Tang, L Ling, N Li, X Jia, Z Zhang, X Wang… - Oncogene, 2018 - nature.com
Breast cancer is a heterogeneous disease, and triple-negative breast cancer (TNBC)
continues to be a serious health problem. The potential involvement of lncRNAs in TNBC …

Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression

BK Yoo, L Emdad, Z Su, A Villanueva… - The Journal of …, 2009 - Am Soc Clin Investig
Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by
diverse etiology, activation of multiple signal transduction pathways, and various gene …

Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes

SG Lee, ZZ Su, L Emdad, P Gupta, D Sarkar… - Journal of Biological …, 2008 - ASBMB
Glutamate is an essential neurotransmitter regulating brain functions. Excitatory amino acid
transporter (EAAT)-2 is one of the major glutamate transporters primarily expressed in …

The multifaceted role of MTDH/AEG-1 in cancer progression

G Hu, Y Wei, Y Kang - Clinical cancer research, 2009 - AACR
Cancer is the result of the progressive acquisition of multiple malignant traits through the
accumulation of genetic or epigenetic alterations. Recent studies have established a …

Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival

J Li, N Zhang, LB Song, WT Liao, LL Jiang… - Clinical cancer …, 2008 - AACR
Purpose: The present study was aimed at clarifying the expression of astrocyte elevated
gene-1 (AEG-1), one of the target genes of oncogenic Ha-ras, in breast cancer and its …

Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer

B Zhang, XX Liu, JR He, CX Zhou, M Guo, M He… - …, 2011 - academic.oup.com
The role of miR-26a in carcinogenesis appears to be a complicated one, in the sense that
both oncogenic and tumor suppressive effects were reported in cancers such as …

Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis

L Emdad, SG Lee, ZZ Su, HY Jeon… - Proceedings of the …, 2009 - National Acad Sciences
Astrocyte-elevated gene-1 (AEG-1) expression is increased in multiple cancers and plays a
central role in Ha-ras-mediated oncogenesis through the phosphatidylinositol 3-kinase …