Abstract Introduction Orofacial clefts (OFCs) are common craniofacial birth defects with
heterogeneous phenotype and etiology. Geneticists have applied nearly every available …

Clefts of the lip and/or palate are the most prevalent orofacial birth defects occurring in about
1: 700 live human births worldwide. Early postnatal surgical interventions are extensive and …

Although de novo mutations (DNMs) are known to increase an individual's risk of congenital
defects, DNMs have not been fully explored regarding orofacial clefts (OFCs), one of the …

Nonsyndromic orofacial cleft (NSOFC) is a severe birth defect that occurs early in embryonic
development and includes the subtypes cleft palate only (CPO), cleft lip only (CLO) and cleft …

Based on epidemiologic and embryologic patterns, nonsyndromic orofacial clefts–the most
common craniofacial birth defects in humans–are commonly categorized into cleft lip with or …

The origin of the jaw is a long-standing problem in vertebrate evolutionary biology. Classical
hypotheses of serial homology propose that the upper and lower jaw evolved through …

Orofacial clefts (OFCs) are among the most prevalent craniofacial birth defects worldwide
and create a significant public health burden. The majority of OFCs are non-syndromic and …

Orofacial clefts (OFCs) are common (1 in 700 births) congenital malformations that include a
cleft lip (CL) and cleft lip and palate (CLP). These OFC subtypes are also heterogeneous …

Cleft lip with or without cleft palate (CL/P) is a common birth defect with a complex,
heterogeneous etiology. It is well established that common and rare sequence variants …

Nonsyndromic orofacial clefts (OFCs) are a common birth defect and are phenotypically
heterogenous in the structure affected by the cleft—cleft lip (CL) and cleft lip and palate …