[HTML][HTML] Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
C Ding, Z Song, A Shen, T Chen, A Zhang - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune
checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by …
checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by …
The role of TBK1 in cancer pathogenesis and anticancer immunity
The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair
The reliance on viral vectors for the production of genetically engineered immune cells for
adoptive cellular therapies remains a translational bottleneck. Here we report a method …
adoptive cellular therapies remains a translational bottleneck. Here we report a method …
Compounds and methods for the enhanced degradation of targeted proteins
AP Crew, CM Crews, X Chen, H Dong… - US Patent …, 2020 - Google Patents
Buckley et al.(Angewandte Chemie, International Edition (2012), 51 (46), 11463-11467).*
Ahn, et al.,“HIF-lalpha peptide derivatives with modifications at the hydroxyproline residue …
Ahn, et al.,“HIF-lalpha peptide derivatives with modifications at the hydroxyproline residue …
[HTML][HTML] Identification of multipotent drugs for COVID-19 therapeutics with the evaluation of their SARS-CoV2 inhibitory activity
The SARS-CoV2 is a highly contagious pathogen that causes COVID-19 disease. It has
affected millions of people globally with an average lethality of~ 3%. There is an urgent need …
affected millions of people globally with an average lethality of~ 3%. There is an urgent need …
Chemical regulation of the cGAS-STING pathway
Nucleic acids represent a major class of pathogen and damage signatures, recognized by a
variety of host sensors to initiate signaling cascades and immune responses, such as …
variety of host sensors to initiate signaling cascades and immune responses, such as …
Roles for the IKK-related kinases TBK1 and IKKε in cancer
While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-
related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic …
related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic …
Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana)
Infectious diseases remain a significant threat to human health, contributing to more than 17
million deaths, annually. With the worsening trends of drug resistance, there is a need for …
million deaths, annually. With the worsening trends of drug resistance, there is a need for …
Targeting pattern-recognition receptors to discover new small molecule immune modulators
G Zhu, Y Xu, X Cen, KS Nandakumar, S Liu… - European Journal of …, 2018 - Elsevier
Pattern recognition receptors (PRRs) are key immune receptors of the innate immune
system, which recognize the conserved pathogen-associated molecular patterns (PAMPs) of …
system, which recognize the conserved pathogen-associated molecular patterns (PAMPs) of …
cGAS–STING, an important signaling pathway in diseases and their therapy
Since cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)–
stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great …
stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great …