Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Acute neurological conditions such as cerebrovascular diseases and trauma are associated
with irreversible loss of neurons and glial cells. Severe or prolonged injury results in …

Background Recently, the use of nanotechnology has been expanding very rapidly in
diverse areas of research, such as consumer products, energy, materials, and medicine …

Doxorubicin (DOX), a widely used chemotherapeutic agent, exhibits cardiotoxicity as an
adverse side effect in cancer patients. DOX-mediated cardiomyopathy is linked to its ability …

Recent epidemiological and clinical data suggest that persons with low folic acid levels and
elevated homocysteine levels are at increased risk of Alzheimer's disease (AD), but the …

Activation of glutamate receptors can trigger the death of neurons and some types of glial
cells, particularly when the cells are coincidentally subjected to adverse conditions such as …

There is currently no approved neuroprotective pharmacotherapy for acute conditions such
as stroke and cerebral asphyxia. One of the reasons for this may be the multiplicity of cell …

Cognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from
the degeneration of synapses and death of neurons in the limbic system and associated …

Multiple molecular, cellular, structural, and functional changes occur in the brain during
aging. Neural cells may respond to these changes adaptively, or they may succumb to …

Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide
(NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in …