Melanoma is a potentially lethal cancer that is most commonly cutaneous. The worldwide
incidence of melanoma has risen rapidly over the course of the last 50 years. Its incidence is …

Melanomas comprise multiple biologically distinct categories, which differ in cell of origin,
age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution …

BACKGROUND: Increasing cutaneous melanoma incidence rates in the United States have
been attributed to heightened detection of thin (≤ 1-mm) lesions. OBJECTIVE: We sought to …

The worldwide incidence of melanoma has increased rapidly over the last 50 years.
Melanoma is the most common cancer found in the young adult population, and its …

Data are presented on the current incidence of melanoma with recent and predicted future
trends illustrating a likely continuing increase in incidence. Risk factors for developing …

The RAS/mitogen-activated protein kinase pathway sends external growth-promoting
signals to the nucleus. BRAF, a critical serine/threonine kinase in this pathway, is frequently …

Cancer incidence and mortality estimates for 1995 are presented for the 38 countries in the
four United Nations-defined areas of Europe, using World Health Organization mortality data …

Every cell in the human body has a unique set of somatic mutations, but it remains difficult to
comprehensively genotype an individual cell. Here we describe ways to overcome this …

This book provides an authoritative guide to the histological and genetic typing of human
tumors of the skin. This volume covers keratinocytic, melanocytic, appendageal …

Converging lines of evidence from varied scientific disciplines suggest that cutaneous
melanomas comprise biologically distinct subtypes that arise through multiple causal …