Immune responses in leishmaniasis: an overview
AC Costa-da-Silva, DO Nascimento… - Tropical medicine and …, 2022 - mdpi.com
Leishmaniasis is a parasitic, widespread, and neglected disease that affects more than 90
countries in the world. More than 20 Leishmania species cause different forms of …
countries in the world. More than 20 Leishmania species cause different forms of …
Regulation of gene expression in trypanosomatids: living with polycistronic transcription
C Clayton - Open biology, 2019 - royalsocietypublishing.org
In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …
[HTML][HTML] Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism
C Bogdan - Cytokine: X, 2020 - Elsevier
Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …
Gene expression in Kinetoplastids
CE Clayton - Current opinion in microbiology, 2016 - Elsevier
Highlights•Kinetoplastids do not control transcription of individual protein-coding
genes.•mRNAs are made from polycistronic precursors by trans splicing and …
genes.•mRNAs are made from polycistronic precursors by trans splicing and …
Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq
Leishmania are protozoan parasites transmitted by the bite of sand fly vectors producing a
wide spectrum of diseases in their mammalian hosts. These diverse clinical outcomes are …
wide spectrum of diseases in their mammalian hosts. These diverse clinical outcomes are …
The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector
E Inbar, VK Hughitt, LAL Dillon, K Ghosh, NM El-Sayed… - MBio, 2017 - Am Soc Microbiol
The life cycle of the Leishmania parasite in the sand fly vector involves differentiation into
several distinctive forms, each thought to represent an adaptation to specific …
several distinctive forms, each thought to represent an adaptation to specific …
Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactions
LAL Dillon, R Suresh, K Okrah, H Corrada Bravo… - BMC genomics, 2015 - Springer
Background Parasites of the genus Leishmania are the causative agents of leishmaniasis, a
group of diseases that range in manifestations from skin lesions to fatal visceral disease …
group of diseases that range in manifestations from skin lesions to fatal visceral disease …
Virulence factors of Leishmania parasite: Their paramount importance in unraveling novel vaccine candidates and therapeutic targets
Leishmaniasis is a neglected tropical disease and remains a global concern for healthcare.
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …
It is caused by an opportunistic protozoan parasite belonging to the genus Leishmania and …
Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures
Macrophages are mononuclear phagocytes that constitute a first line of defense against
pathogens. While lethal to many microbes, they are the primary host cells of Leishmania …
pathogens. While lethal to many microbes, they are the primary host cells of Leishmania …
Function of macrophage and parasite phosphatases in leishmaniasis
The kinetoplastid protozoan parasites belonging to the genus Leishmania are the causative
agents of different clinical forms of leishmaniasis, a vector-borne infectious disease with …
agents of different clinical forms of leishmaniasis, a vector-borne infectious disease with …