The biology, function, and biomedical applications of exosomes

R Kalluri, VS LeBleu - Science, 2020 - science.org
BACKGROUND All cells, prokaryotes and eukaryotes, release extracellular vesicles (EVs)
as part of their normal physiology and during acquired abnormalities. EVs can be broadly …

[HTML][HTML] Exosome theranostics: biology and translational medicine

C He, S Zheng, Y Luo, B Wang - Theranostics, 2018 - ncbi.nlm.nih.gov
Exosomes are common membrane-bound nanovesicles that contain diverse biomolecules,
such as lipids, proteins, and nucleic acids. Exosomes are derived from cells through …

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

M Pathan, P Fonseka, SV Chitti, T Kang… - Nucleic acids …, 2019 - academic.oup.com
Extracellular vesicles (EVs) are membranous vesicles that are released by both prokaryotic
and eukaryotic cells into the extracellular microenvironment. EVs can be categorised as …

Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake

ER Abels, XO Breakefield - Cellular and molecular neurobiology, 2016 - Springer
Extracellular vesicles are a heterogeneous group of membrane-limited vesicles loaded with
various proteins, lipids, and nucleic acids. Release of extracellular vesicles from its cell of …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

ExoCarta: a web-based compendium of exosomal cargo

S Keerthikumar, D Chisanga, D Ariyaratne… - Journal of molecular …, 2016 - Elsevier
Exosomes are membranous vesicles that are released by a variety of cells into the
extracellular microenvironment and are implicated in intercellular communication. As …

Focus on extracellular vesicles: introducing the next small big thing

H Kalra, GPC Drummen, S Mathivanan - International journal of molecular …, 2016 - mdpi.com
Intercellular communication was long thought to be regulated exclusively through direct
contact between cells or via release of soluble molecules that transmit the signal by binding …

[HTML][HTML] Neural stem cells traffic functional mitochondria via extracellular vesicles

L Peruzzotti-Jametti, JD Bernstock, CM Willis… - PLoS …, 2021 - journals.plos.org
Neural stem cell (NSC) transplantation induces recovery in animal models of central
nervous system (CNS) diseases. Although the replacement of lost endogenous cells was …

Understanding the extracellular vesicle surface for clinical molecular biology

S Hallal, Á Tűzesi, GE Grau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐membrane enclosed nanoparticles that play significant
roles in health and disease. EVs are abundant in body fluids and carry an array of molecules …

Insight into extracellular vesicle-cell communication: from cell recognition to intracellular fate

L Ginini, S Billan, E Fridman, Z Gil - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous
structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and …