Background Sepsis and bloodstream infection are associated with significant morbidity and
mortality, and early effective antimicrobial therapy has been demonstrated to improve patient …

This review delves into the rapidly evolving landscape of liquid biopsy technologies based
on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in …

Background Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA
has emerged as a promising diagnostic technology for bloodstream infections. However, a …

Metagenomic next-generation sequencing (mNGS) of microbial cell-free DNA (mcfDNA
sequencing) is becoming an attractive diagnostic modality for infectious diseases, allowing …

Many common pathogens are difficult or impossible to detect using conventional
microbiological tests. However, the rapid and untargeted nature of metagenomic next …

Objectives: The aim of this study is to investigate the clinical usefulness of metagenomic
Next-generation sequencing (mNGS) on bronchoalveolar lavage fluid (BALF) samples to …

Metagenomic next-generation sequencing (mNGS) and droplet digital PCR (ddPCR) have
recently demonstrated a great potential for pathogen detection. However, few studies have …

Background Plasma microbial cell-free DNA sequencing (mcfDNA-Seq) is a noninvasive
test for microbial diagnosis of invasive mold infection (IMI). The utility of mcfDNA-Seq for …

Background Microbial cell-free DNA (mcfDNA) sequencing of plasma can identify the
presence of a pathogen in a host. In this study, we evaluated the duration of pathogen …

Antimicrobial resistance (AMR) has become a global medical priority that needs urgent
resolution. Pseudomonas aeruginosa is a versatile, adaptable bacterial species with …