The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells
promotes their decline, while misrepair of this damage initiates malignancies. Here we …

Precise gene editing in hematopoietic stem and progenitor cells (HSPCs) holds promise for
treating genetic diseases. However, responses triggered by programmable nucleases in …

Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …

Targeted gene editing in hematopoietic stem cells (HSCs) is a promising treatment for
several diseases. However, the limited efficiency of homology-directed repair (HDR) in …

Programmed cell death (PCD) plays a fundamental role in animal development and tissue
homeostasis. Abnormal regulation of this process is associated with a wide variety of human …

Targeted genome editing by artificial nucleases has brought the goal of site-specific
transgene integration and gene correction within the reach of gene therapy. However, its …

Despite its complexity, blood is probably the best understood developmental system, largely
due to seminal experimentation in the mouse. Clinically, hematopoietic stem cell (HSC) …

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …