The central nervous system (CNS) and the immune system are both intricate and highly
organized systems that regulate the entire body, with both sharing certain common features …

With a worldwide incidence of 15 million cases, preterm birth is a major contributor to
neonatal mortality and morbidity, and concomitant social and economic burden Preterm …

Necrotizing enterocolitis (NEC) causes acute intestinal necrosis in premature infants and is
associated with severe neurological impairment. In NEC, Toll-like receptor 4 is activated in …

Perinatal brain injury is the leading cause of neurological mortality and morbidity in
childhood ranging from motor and cognitive impairment to behavioural and neuropsychiatric …

Ferroptosis is an iron-dependent form of cell death that is characterized by early lipid
peroxidation and different from other forms of regulated cell death in terms of its genetic …

Background and Purpose: Neonatal encephalopathy caused by hypoxia-ischemia (HI) is a
major cause of death and disability in newborns. Clinical and experimental studies suggest …

We recently reported that neonatal ischemia induces microglia/macrophage activation three
days post-ischemia. We also found that female mice sustained smaller infarcts than males …

Hypoxic-ischemic injury to the developing brain remains a major cause of significant long-
term morbidity and mortality. Emerging evidence from neonatal brain injury models suggests …

The meninges are important for brain development and pathology. Using single-cell RNA
sequencing, we have generated the first comprehensive transcriptional atlas of neonatal …

The peripheral immune system plays a critical role in neuroinflammation of the central
nervous system after an insult. Hypoxic-ischemic encephalopathy (HIE) induces a strong …