The growing number of studies on G protein-coupled receptors (GPCRs) family are a source
of noticeable improvement in our understanding of the functioning of these proteins. GPCRs …

G protein-coupled receptors represent the largest family of human membrane proteins and
are modulated by a variety of drugs and endogenous ligands. Molecular modeling …

In order to target behavioral and psychological symptoms of dementia (BPSD), we used
molecular modeling-assisted design to obtain novel multifunctional arylsulfonamide …

In our research to find new dual 5-HT 1A/5-HT 7 ligands from the long-chain arylpiperazine
(LCAP) family, we applied a new synthesis method with the support of ultrasound. The first …

Recent breakthroughs in crystallographic studies of G protein-coupled receptors (GPCRs),
together with continuous progress in molecular modeling methods, have opened new …

Schizophrenia is a chronic mental illness, which remains difficult to treat. A high resistance
to the available therapies, their insufficient efficacy, and numerous side effects are the …

Trazodone, a well-known antidepressant drug widely used throughout the world, works as a
5-hydroxytryptamine (5-HT2) and α1-adrenergic receptor antagonist and a serotonin …

The functioning of GPCRs is classically described by the ternary complex model as the
interplay of three basic components: a receptor, an agonist, and a G protein. According to …

Continuing our earlier study in a group of purine-2, 6-dione derivatives of long chain
arylpiperazines (LCAPs), a series of 8-unsubstituted 7-phenylpiperazin-4-yl-alkyl (4–14) and …

A series of novel spirohydantoin derivatives with arylpiperazinylbutyl moiety were
synthesized and evaluated for serotonin 5-HT 1A, 5-HT 2A, 5-HT 7 and dopamine D 2 …