Regulation of proliferation, differentiation and functions of osteoblasts by Runx2
T Komori - International journal of molecular sciences, 2019 - mdpi.com
Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During
osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells …
osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells …
Whole aspect of Runx2 functions in skeletal development
T Komori - International Journal of Molecular Sciences, 2022 - mdpi.com
Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …
development. In endochondral ossification, Runx2 induces chondrocyte maturation …
Runx2, an inducer of osteoblast and chondrocyte differentiation
T Komori - Histochemistry and cell biology, 2018 - Springer
Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …
Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation
Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …
Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …
[HTML][HTML] Molecular mechanism of Runx2-dependent bone development
T Komori - Molecules and cells, 2020 - Elsevier
Runx2 is an essential transcription factor for skeletal development. It is expressed in
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …
multipotent mesenchymal cells, osteoblast-lineage cells, and chondrocytes. Runx2 plays a …
[PDF][PDF] Role and regulation of RUNX2 in osteogenesis
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
The RUNX family: developmental regulators in cancer
Y Ito, SC Bae, LSH Chuang - Nature Reviews Cancer, 2015 - nature.com
RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …
regulators of development. They are frequently deregulated in human cancers, indicating a …
The development of molecular biology of osteoporosis
Y Gao, S Patil, J Jia - International journal of molecular sciences, 2021 - mdpi.com
Osteoporosis is one of the major bone disorders that affects both women and men, and
causes bone deterioration and bone strength. Bone remodeling maintains bone mass and …
causes bone deterioration and bone strength. Bone remodeling maintains bone mass and …
Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3
T Kawane, X Qin, Q Jiang, T Miyazaki, H Komori… - Scientific reports, 2018 - nature.com
Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the
molecular mechanisms responsible for the proliferation of osteoblast progenitors remain …
molecular mechanisms responsible for the proliferation of osteoblast progenitors remain …