TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone
Antagonist Trial) trial for efficacy in HF with preserved ejection fraction (HFPEF), a disease …

We will shortly celebrate the 25th anniversary of the publication of the Co-operative North
Scandinavian Enalapril Survival Study (CONSENSUS), a clinical trial which revolutionized …

Importance Hospitalizations for heart failure (HHF) represent a major health burden, with
high rates of early postdischarge rehospitalization and mortality. Objective To investigate …

1022 Circulation August 27, 2013 dehydrogenase activity. 14 Increases in cardiac
aldosterone have been reported in experimental models of myocardial infarction, 15 …

Blockade of the renin–angiotensin system (RAS) is a core therapeutic strategy in systolic
heart failure. 1 The value of angiotensinconverting enzyme (ACE) inhibitors was proven in …

Aims Troponin levels are commonly elevated among patients hospitalized for heart failure
(HF), but the prevalence and prognostic significance of early post‐discharge troponin …

Aims The direct renin inhibitor, aliskiren, is known to reduce plasma renin activity (PRA), but
whether the efficacy of aliskiren varies based on an individual's baseline PRA in patients …

To investigate the antihypertensive effects and tolerability of aliskiren in comparison with
other antihypertensive drugs and placebo in patients with hypertension, a meta-analysis …

Heart failure (HF) is a major public health priority due to its epidemiological transition and
the world's aging population. HF is typified by continuous loss of contractile function with …

Current data suggest that patients with HHF have lower inhospital but higher postdischarge
risk for adverse events compared with patients with acute myocardial infarction. The patients …