Novel prognostic clinical factors and biomarkers for outcome prediction in head and neck cancer: a systematic review

V Budach, I Tinhofer - The Lancet Oncology, 2019 - thelancet.com
Current algorithms for the clinical management of patients with squamous cell carcinoma of
the head and neck (HNSCC) are based on a stage-dependent strategy where all patients at …

Concurrent chemoradiotherapy vs. radiotherapy alone in locally advanced cervix cancer: a systematic review and meta-analysis

NR Datta, E Stutz, M Liu, S Rogers, D Klingbiel… - Gynecologic …, 2017 - Elsevier
The efficacy of concurrent chemoradiotherapy (CTRT) in locally advanced cervix cancer
(LACC, stages IIB-IVA) is contentious. This is due to the variable extent of therapeutic benefit …

Cell‐free human papillomavirus DNA kinetics after surgery for human papillomavirus–associated oropharyngeal cancer

CJ O'Boyle, G Siravegna, S Varmeh, N Queenan… - Cancer, 2022 - Wiley Online Library
Background New ultrasensitive methods for detecting residual disease after surgery are
needed in human papillomavirus–associated oropharyngeal squamous cell carcinoma …

Cetuximab-containing combinations in locally advanced and recurrent or metastatic head and neck squamous cell carcinoma

M Taberna, M Oliva, R Mesía - Frontiers in oncology, 2019 - frontiersin.org
Cetuximab remains to date the only targeted therapy approved for the treatment of head and
neck squamous cell carcinoma (HNSCC). The EGFR pathway plays a key role in the …

Standard of care vs reduced-dose chemoradiation after induction chemotherapy in HPV+ oropharyngeal carcinoma patients: The Quarterback trial

K Misiukiewicz, V Gupta, BA Miles, R Bakst, E Genden… - Oral oncology, 2019 - Elsevier
Abstract Background Human Papillomavirus oropharyngeal carcinoma (HPVOPC) has
better progression free (PFS) and overall survival (OS) than non-HPVOPC. Standard-dose …

Systematic review and meta-analyses of intensity-modulated radiation therapy versus conventional two-dimensional and/or or three-dimensional radiotherapy in …

T Gupta, S Kannan, S Ghosh-Laskar, JP Agarwal - PloS one, 2018 - journals.plos.org
Introduction Technological advancements in treatment planning and delivery have propelled
the use of intensity-modulated radiation therapy (IMRT) in head and neck squamous cell …

HPV circulating tumoral DNA quantification by droplet‐based digital PCR: a promising predictive and prognostic biomarker for HPV‐associated oropharyngeal …

D Veyer, M Wack, M Mandavit… - … journal of cancer, 2020 - Wiley Online Library
We aimed to determine whether pretherapeutic assessment of HPV circulating tumoral DNA
(HPV ctDNA) by droplet‐based digital PCR (ddPCR) could constitute a predictive and …

Radiomic biomarkers to refine risk models for distant metastasis in HPV-related oropharyngeal carcinoma

JYY Kwan, J Su, SH Huang, LS Ghoraie, W Xu… - International Journal of …, 2018 - Elsevier
Purpose Distant metastasis (DM) is the main cause of death for patients with human
papillomavirus (HPV)–related oropharyngeal cancers (OPCs); yet, there are few reliable …

Appraisal of the AJCC 8th edition pathologic staging modifications for HPV− positive oropharyngeal cancer, a study of the National Cancer Data Base

KY Zhan, A Eskander, SY Kang, MO Old, E Ozer… - Oral oncology, 2017 - Elsevier
Abstract Background The American Joint Commission on Cancer (AJCC) recently created
new staging for human papillomavirus associated oropharyngeal cancer (HPV+ OPSCC) for …

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification

PYF Zeng, MJ Cecchini, JW Barrett… - …, 2022 - thelancet.com
Background There is significant interest in treatment de-escalation for human papillomavirus-
associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the …