In the body, cells encounter a complex milieu of signals, including topographical cues, in the
form of the physical features of their surrounding environment. Imposed topography can …

Spinal cord injury (SCI) results in permanent loss of function leading to often devastating
personal, economic and social problems. A contributing factor to the permanence of SCI is …

Our long-term goal is to develop an artificial implant as a conduit for axonal regeneration
after peripheral nerve injury. In this study, biodegradable, aligned poly-ε-caprolactone (PCL) …

Although several approaches to stimulate axonal regeneration after spinal cord injury have
succeeded in stimulating robust growth of axons into a lesion site, the growth is generally …

Three-dimensional (3D) gelatin sponge (GS) scaffolds were constructed by ensheathing GS
with a thin film of poly-(lactide-co-glycolide)(PLGA). Rat bone marrow-derived mesenchymal …

Nerve regeneration in an injured spinal cord is often restricted, contributing to the
devastating outcome of neurologic impairment below the site of injury. Although implantation …

While several strategies can stimulate axonal regeneration within a site of spinal cord injury,
the growth of axons is generally disorganized and random. Biocompatible scaffolds that …

Spinal cord injury (SCI) is a common outcome of traffic accidents and trauma with severe
consequences. There has been no cure for such a condition. We performed experiments to …

After injury to the spinal cord, reactive astrocytes form a glial scar consisting of highly
ramified cell processes that constitute a major impediment to repair, partly due to their lack of …

Spinal cord injury results in the loss of motor and sensory pathways and spontaneous
regeneration of adult mammalian spinal cord neurons is limited. Chitosan and sodium …