The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

Single-cell RNA sequencing can reveal the transcriptional state of cells, yet provides little
insight into the upstream regulatory landscape associated with open or accessible …

Neurons, astrocytes and oligodendrocytes arise from CNS progenitor cells at defined times
and locations during development, with transcription factors serving as key determinants of …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

Abstract Analysis of chromatin accessibility can reveal transcriptional regulatory sequences,
but heterogeneity of primary tissues poses a significant challenge in mapping the precise …

Astrocytes can be generated from various tissue sources including human pluripotent stem
cells (PSC). In this manuscript, we describe a chemically defined xeno-free medium culture …

Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the
developing human cortex that contribute to its cellular diversity and evolutionary expansion …

Despite widespread interest in using human induced pluripotent stem cells (hiPSCs) in
neurological disease modeling, a suitable model system to study human neuronal …

Autism spectrum disorders (ASD) are neurodevelopmental disorders with phenotypic and
genetic heterogeneity. Recent studies have reported rare and de novo mutations in ASD, but …

A broad molecular framework of how neural stem cells are specified toward astrocyte fate
during brain development has proven elusive. Here we perform comprehensive and …