[HTML][HTML] Considerations for polymers used in ocular drug delivery

MM Allyn, RH Luo, EB Hellwarth… - Frontiers in …, 2022 - frontiersin.org
Purpose Age-related eye diseases are becoming more prevalent. A notable increase has
been seen in the most common causes including glaucoma, age-related macular …

Clinical pharmacology of intravitreal anti-VEGF drugs

S Fogli, M Del Re, E Rofi, C Posarelli, M Figus… - Eye, 2018 - nature.com
Clinical efficacy of intravitreal anti-VEGF drugs has been widely demonstrated in several
angiogenesis-driven eye diseases including diabetic macular edema and the neovascular …

[HTML][HTML] Exosomes derived from mesenchymal stem cells modulate miR-126 to ameliorate hyperglycemia-induced retinal inflammation via targeting HMGB1

W Zhang, Y Wang, Y Kong - Investigative ophthalmology & …, 2019 - iovs.arvojournals.org
Purpose: In this study, we aim to investigate whether mesenchymal stem cell (MSC)-derived
exosomes (MSC-Exos) could regulate hyperglycemia-induced retinal inflammation by …

[HTML][HTML] The role of inflammation in immune system of diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

T Yue, Y Shi, S Luo, J Weng, Y Wu… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy is one of the most common complications of diabetes mellitus and the
leading cause of low vision and blindness worldwide. Mounting evidence demonstrates that …

Retinal vascular cystoid macular edema: review and new theory

RF Spaide - Retina, 2016 - journals.lww.com
Retinal vascular disease has the potential to affect hundreds of millions of people, with the
inherent risk of vision loss related to cystoid macular edema. Although there have been …

How to prevent the microvascular complications of type 2 diabetes beyond glucose control

WM Valencia, H Florez - Bmj, 2017 - bmj.com
Microvascular complications (retinopathy, nephropathy, and neuropathy) affect hundreds of
millions of patients with type 2 diabetes. They usually affect people with longstanding or …

Biological drug therapy for ocular angiogenesis: Anti‐VEGF agents and novel strategies based on nanotechnology

ML Formica, HG Awde Alfonso… - Pharmacology Research …, 2021 - Wiley Online Library
Currently, biological drug therapy for ocular angiogenesis treatment is based on the
administration of anti‐VEGF agents via intravitreal route. The molecules approved with this …

[HTML][HTML] Visualization of changes in the foveal avascular zone in both observed and treated diabetic macular edema using optical coherence tomography angiography

A Gill, ED Cole, EA Novais, RN Louzada… - International journal of …, 2017 - Springer
Background Central vision loss in diabetic retinopathy is commonly related to diabetic
macular edema (DME). The objective of this study was to describe changes between …

Recent perspectives on the delivery of biologics to back of the eye

M Joseph, HM Trinh, K Cholkar, D Pal… - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: Biologics are generally macromolecules, large in size with poor stability in
biological environments. Delivery of biologics to tissues at the back of the eye remains a …

Single-cell and bulk transcriptomics reveals M2d macrophages as a potential therapeutic strategy for mucosal healing in ulcerative colitis

W Lai, C Xian, M Chen, D Luo, J Zheng, S Zhao… - International …, 2023 - Elsevier
Mucosal healing is essential for treating ulcerative colitis (UC), which results from
imbalanced macrophage polarization and dysregulated inflammatory responses. However …