Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
[HTML][HTML] Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data
TJ Morris, S Beck - Methods, 2015 - Elsevier
Abstract The Illumina HumanMethylation450 BeadChip has become a popular platform for
interrogating DNA methylation in epigenome-wide association studies (EWAS) and related …
interrogating DNA methylation in epigenome-wide association studies (EWAS) and related …
[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays
Abstract Motivation: The recently released Infinium HumanMethylation450 array (the
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …
Obesity accelerates epigenetic aging of human liver
S Horvath, W Erhart, M Brosch… - Proceedings of the …, 2014 - National Acad Sciences
Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that
obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to …
obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to …
Sex differences in DNA methylation assessed by 450 K BeadChip in newborns
Background DNA methylation is an important epigenetic mark that can potentially link early
life exposures to adverse health outcomes later in life. Host factors like sex and age strongly …
life exposures to adverse health outcomes later in life. Host factors like sex and age strongly …
[HTML][HTML] The cerebellum ages slowly according to the epigenetic clock
S Horvath, V Mah, AT Lu, JS Woo, OW Choi… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
Studies that elucidate why some human tissues age faster than others may shed light on
how we age, and ultimately suggest what interventions may be possible. Here we utilize a …
how we age, and ultimately suggest what interventions may be possible. Here we utilize a …
Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array
Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly
evolving, as are the options for applicable bioinformatics methods. The most commonly used …
evolving, as are the options for applicable bioinformatics methods. The most commonly used …
Cohort profile: pregnancy and childhood epigenetics (PACE) consortium
JF Felix, BR Joubert, AA Baccarelli… - International journal …, 2018 - academic.oup.com
Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA
sequence, but can influence its function. Currently, DNA methylation is the most studied …
sequence, but can influence its function. Currently, DNA methylation is the most studied …
RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip
Abstract Background The Illumina Infinium HumanMethylation450 BeadChip and its
successor, Infinium MethylationEPIC BeadChip, have been extensively utilized in …
successor, Infinium MethylationEPIC BeadChip, have been extensively utilized in …