Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …

Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Deracemization, which converts a racemate into its single enantiomer without separation of
the intermediate, has gained renewed interest in asymmetric synthesis with its inherent …

Amines constitute the major targets for the production of a plethora of chemical compounds
that have applications in the pharmaceutical, agrochemical and bulk chemical industries …

Oxidation is one of the most important processes used by the chemical industry. However,
many of the methods that are used pose significant sustainability and environmental issues …

The asymmetric reductive amination of ketones with ammonia using engineered amine
dehydrogenases (AmDHs) is a particularly attractive and environmentally friendly method for …

Monoamine oxidases (MAO) are biocatalysts for the oxidation of a wide range of different
amines including α-chiral amines. Their high selectivity and activity, along with the …

Enzymes have been used for a long time as catalysts in the asymmetric synthesis of chiral
intermediates needed in the production of therapeutic drugs. However, this alternative to …

A new directed evolution approach is presented to enhance the activity of an enzyme and to
manipulate stereoselectivity by focusing iterative saturation mutagenesis (ISM) …