Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

Stress and the resulting increase in glucocorticoid levels have been implicated in the
pathophysiology of depressive disorders. We investigated the effects of chronic restraint …

Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …

The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …

Neurotrophic factors, a family of secreted proteins that support the growth, survival and
differentiation of neurons, have been intensively studied for decades due to the powerful …

Women are twice as likely as men to develop major depressive disorder (MDD) and are
more prone to recurring episodes. Hence, we tested the hypothesis that the illness may …

Mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BPD), are
the most prevalent psychiatric conditions, and are also among the most severe and …