Early developmental conditioning of later health and disease: physiology or pathophysiology?
MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …
environmental influences during early development affect the risk of later pathophysiological …
Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease
Noncoding repeat expansions cause various neuromuscular diseases, including myotonic
dystrophies, fragile X tremor/ataxia syndrome, some spinocerebellar ataxias, amyotrophic …
dystrophies, fragile X tremor/ataxia syndrome, some spinocerebellar ataxias, amyotrophic …
Methodological aspects of whole-genome bisulfite sequencing analysis
The combination of DNA bisulfite treatment with high-throughput sequencing technologies
has enabled investigation of genome-wide DNA methylation beyond CpG sites and CpG …
has enabled investigation of genome-wide DNA methylation beyond CpG sites and CpG …
Whole‐genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer
Background Cancer cell–specific variation and circulating tumour DNA (ctDNA) methylation
are promising biomarkers for non‐invasive cancer detection and molecular classification …
are promising biomarkers for non‐invasive cancer detection and molecular classification …
Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation
DNA methylation is a crucial epigenetic modification in the establishment of cell-type-
specific characteristics. However, how DNA methylation is selectively reprogrammed at …
specific characteristics. However, how DNA methylation is selectively reprogrammed at …
Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific …
DNA methylation is a key epigenetic mark that is critical for gene regulation in multicellular
eukaryotes. Although various human cell types may have the same genome, these cells …
eukaryotes. Although various human cell types may have the same genome, these cells …
A survey of the approaches for identifying differential methylation using bisulfite sequencing data
DNA methylation is an important epigenetic mechanism that plays a crucial role in cellular
regulatory systems. Recent advancements in sequencing technologies now enable us to …
regulatory systems. Recent advancements in sequencing technologies now enable us to …
DNA methylation in obesity and type 2 diabetes
VDF de Mello, L Pulkkinen, M Lalli… - Annals of …, 2014 - Taylor & Francis
To elucidate the mechanisms related to the development of type 2 diabetes (T2D) and other
degenerative diseases at a molecular level, a better understanding of the changes in the …
degenerative diseases at a molecular level, a better understanding of the changes in the …
swDMR: a sliding window approach to identify differentially methylated regions based on whole genome bisulfite sequencing
DNA methylation is a widespread epigenetic modification that plays an essential role in
gene expression through transcriptional regulation and chromatin remodeling. The …
gene expression through transcriptional regulation and chromatin remodeling. The …
Methods for identifying differentially methylated regions for sequence-and array-based data
DNA methylation is one of the most important epigenetic mechanisms, and participates in
the pathogenic processes of many diseases. Differentially methylated regions (DMRs) in the …
the pathogenic processes of many diseases. Differentially methylated regions (DMRs) in the …