Myelination of axons provides the structural basis for rapid saltatory impulse propagation
along vertebrate fiber tracts, a well-established neurophysiological concept. However …

The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass
from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in …

Calcium is the most universal signal used by living organisms to convey information to many
different cellular processes. In this review we present well-known and recently identified …

To determine whether L-type voltage-operated Ca2+ channels (L-VOCCs) are required for
oligodendrocyte progenitor cell (OPC) development, we generated an inducible conditional …

Multiple sclerosis is believed to be mediated by T cells specific for myelin antigens that
circulate harmlessly in the periphery of healthy individuals until they are erroneously …

Background Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of
myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis …

It has become clear that the products of several of the earliest identified myelin protein
genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin …

Rapid nerve conduction in jawed vertebrates is facilitated by the myelination of axons, which
evolved in ancient cartilaginous fish. We aim to understand the coevolution of myelin and …

Calcium influx is crucial for T cell activation and differentiation. The detailed regulation of this
process remains unclear. We report here that golli protein, an alternatively spliced product of …

The myelin basic protein (MBP) family comprises a variety of developmentally-regulated
members arising from different transcription start sites, differential splicing, and post …