[HTML][HTML] Selenium and selenoproteins in health
F Zhang, X Li, Y Wei - Biomolecules, 2023 - mdpi.com
Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …
taken up by the liver, selenium performs various physiological functions in the body in the …
[HTML][HTML] Role of the immune system in the development of the central nervous system
K Morimoto, K Nakajima - Frontiers in Neuroscience, 2019 - frontiersin.org
The central nervous system (CNS) and the immune system are both intricate and highly
organized systems that regulate the entire body, with both sharing certain common features …
organized systems that regulate the entire body, with both sharing certain common features …
Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
Mechanisms for T cell receptor triggering
PA Van Der Merwe, O Dushek - Nature Reviews Immunology, 2011 - nature.com
There is considerable controversy about the mechanism of T cell receptor (TCR) triggering,
the process by which the TCR tranduces signals across the plasma membrane after binding …
the process by which the TCR tranduces signals across the plasma membrane after binding …
[HTML][HTML] The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells
J Li, Z Xiao, D Wang, L Jia, S Nie, X Zeng, W Hu - Molecular Cancer, 2023 - Springer
Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …
The kinetic-segregation model: TCR triggering and beyond
SJ Davis, PA Van Der Merwe - Nature immunology, 2006 - nature.com
How the T cell receptor engages antigen is known, but not how that'triggers' intracellular
signaling. The first direct support for a mechanism based on the spatial reorganization of …
signaling. The first direct support for a mechanism based on the spatial reorganization of …
[HTML][HTML] Regulation of T cell receptor activation by dynamic membrane binding of the CD3ɛ cytoplasmic tyrosine-based motif
Many immune system receptors signal through cytoplasmic tyrosine-based motifs (ITAMs),
but how receptor ligation results in ITAM phosphorylation remains unknown. Live-cell …
but how receptor ligation results in ITAM phosphorylation remains unknown. Live-cell …
Early events in B cell activation
NE Harwood, FD Batista - Annual review of immunology, 2009 - annualreviews.org
B cell activation is initiated by the ligation of the B cell receptor (BCR) with antigen and
ultimately results in the production of protective antibodies against potentially pathogenic …
ultimately results in the production of protective antibodies against potentially pathogenic …
The optimal antigen response of chimeric antigen receptors harboring the CD3ζ transmembrane domain is dependent upon incorporation of the receptor into the …
JS Bridgeman, RE Hawkins, S Bagley… - The Journal of …, 2010 - journals.aai.org
Abstract Chimeric Ag receptors (CARs) expressed in T cells permit the redirected lysis of
tumor cells in an MHC-unrestricted manner. In the Jurkat T cell model system, expression of …
tumor cells in an MHC-unrestricted manner. In the Jurkat T cell model system, expression of …
CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy
J Rosenberg, J Huang - Current opinion in chemical engineering, 2018 - Elsevier
Highlights•CD8+ T cells and NK cells are both cytotoxic cells with engineering potential.•NK
cells are comparable to CD8+ T cells but far less understood.•Cancer immunotherapies …
cells are comparable to CD8+ T cells but far less understood.•Cancer immunotherapies …