Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …

The central nervous system (CNS) and the immune system are both intricate and highly
organized systems that regulate the entire body, with both sharing certain common features …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

There is considerable controversy about the mechanism of T cell receptor (TCR) triggering,
the process by which the TCR tranduces signals across the plasma membrane after binding …

Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

How the T cell receptor engages antigen is known, but not how that'triggers' intracellular
signaling. The first direct support for a mechanism based on the spatial reorganization of …

Many immune system receptors signal through cytoplasmic tyrosine-based motifs (ITAMs),
but how receptor ligation results in ITAM phosphorylation remains unknown. Live-cell …

B cell activation is initiated by the ligation of the B cell receptor (BCR) with antigen and
ultimately results in the production of protective antibodies against potentially pathogenic …

Abstract Chimeric Ag receptors (CARs) expressed in T cells permit the redirected lysis of
tumor cells in an MHC-unrestricted manner. In the Jurkat T cell model system, expression of …

Highlights•CD8+ T cells and NK cells are both cytotoxic cells with engineering potential.•NK
cells are comparable to CD8+ T cells but far less understood.•Cancer immunotherapies …