Cadherins and catenins represent key molecules during development. Recent findings
demonstrate the involvement of cadherins and catenins in signaling pathways. In a working …

The organization of metazoa is based on the formation of tissues and on tissue-typical
functions and these in turn are based on cell–cell connecting structures. In vertebrates, four …

Incomplete repair after acute kidney injury can lead to development of chronic kidney
disease. To define the mechanism of this response, we compared mice subjected to …

Human pluripotent stem cells (hPSCs) can generate a diversity of cell types, but few
methods have been developed to derive cells of the kidney lineage. Here, we report a highly …

During embryonic development, the kidney epithelium originates from cells that undergo a
mesenchymal to epithelial transition (MET). The reverse process, epithelium to mesenchyme …

Ksp-cadherin is a unique, tissue-specific member of the cadherin family of cell adhesion
molecules that is expressed in tubular epithelial cells in the kidney and developing …

A newly identified gene, H–cadherin, is reported. H–cadherin encodes a protein related to
the cadherin superfamily of cell adhesion molecules, and its expression is shown to be …

Acute kidney injury (AKI) is a common clinical condition of growing incidence. Patients who
suffer severe AKI have a higher risk of developing interstitial fibrosis, chronic kidney disease …

The renal proximal tubule is a main target for drug-induced toxicity. The prediction of
proximal tubular toxicity during drug development remains difficult. Any in vitro methods …

Background The classical cadherins such as E-and N-cadherin are Ca 2+-dependent cell
adhesion molecules that play important roles in the development and maintenance of renal …