Background & Aims In mice, activation of the transient receptor potential cation channels
(TRP) TRPV1, TRPV4, and TRPA1 causes visceral hypersensitivity. These receptors and …

While proteases are essential in gastrointestinal physiology, accumulating evidence
indicates that dysregulated proteolysis plays a pivotal role in the pathophysiology of …

The epidemic of diabetes mellitus is worsening worldwide. Diabetes mellitus is a chronic
metabolic disease characterized by inappropriate recurrent or persistent hyperglycemia …

The underlying mechanisms and treatment of painful temporomandibular disorders (TMDs)
are important but understudied topics in craniofacial research. As a group of …

Targeted therapy to prevent the progression from acute to chronic pain in cancer patients
remains elusive. We developed three novel cancer models in mice that together recapitulate …

Background Periodontitis (PD) may affect temporomandibular joint disorders (TMD) and
TMD may influence PD in previous observational studies. Nevertheless, these studies were …

Objective To determine whether activation of transient receptor potential vanilloid 4 (TRPV‐
4) induces inflammation in the rat temporomandibular joint (TMJ), and to assess the effects …

This study analyzed the effects of photobiomodulation (PBM) with low-level laser therapy on
nociceptive behavior and neuronal activity in the trigeminal nucleus after experimental …

This study investigated the antinociceptive and anti-inflammatory effects of
electroacupuncture (EA) on zymosan-induced acute arthritis of the rat temporomandibular …

Background Increasing evidences indicate that an unbalance between tryptases and their
endogenous inhibitors, leading to an increased proteolytic activity, is implicated in the …