Metabolic plasticity, which determines tumour growth and metastasis, is now understood to
be a flexible and context-specific process in cancer metabolism. One of the major pathways …

Redox-mediated posttranslational modification, as exemplified by protein S-nitrosylation,
modulates protein activity and function in both health and disease. Here, we review recent …

Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease,
which has a high heritability of up to 79%. Exploring the genetic basis is essential for …

Aims Transient receptor potential canonical 5 (TRPC5) channels are redox-sensitive cation-
permeable channels involved in temperature and mechanical sensation. Increased …

Hyperactivation of the NLRP3 inflammasome has been implicated in the pathogenesis of
numerous diseases. However, the precise molecular mechanisms that modulate the …

Alzheimer's disease (AD) is the most common chronic progressive neurodegenerative
disease in the elderly. It has an increasing prevalence and a growing health burden. One of …

Morphine, a typical opiate, is widely used for controlling pain but can lead to various side
effects with long-term use, including addiction, analgesic tolerance, and hyperalgesia. At …

Physical exercise has beneficial effect on anxiety disorders, but the underlying molecular
mechanism remains largely unknown. Here, it is demonstrated that physical exercise can …

Traumatic brain injury (TBI) has the highest incidence of all common neurological disorders,
along with high mortality and disability rates. Pathological conversion of excess nitric oxide …

Objective: To analyze the effects of S-nitrosoglutathione reductase (GSNOR) inhibitor
(N6022) on diabetic lower extremity vascular dysfunction and its mechanism. Methods: Sixty …