Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

Cardiovascular diseases (CVDs) such as atherosclerosis, myocardial remodeling,
myocardial ischemia-reperfusion (I/R) injury, heart failure, and oxidative stress are among …

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …

Intervertebral disc degeneration (IVDD) is a chronic age-related degenerative disease
accompanied by complex pathophysiological mechanisms. Increasing evidence indicates …

Pyroptosis mediated by nucleotide-binding oligomerization domain (NOD)-like receptor 3
(NLRP3) inflammasome is implicated in cerebral ischemia/reperfusion (I/R) injury …

Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …

Daphnetin (DAP), a coumarin derivative extracted from Daphne species, is biologically
active phytochemical with copious bioactivities including anti-inflammatory, anti-oxidant …

Inflammatory bowel disease (IBD) is a non-communicable disease characterized by a
chronic inflammatory process of the gut and categorized into Crohn's disease and ulcerative …

Glyphosate (Gly) is an active ingredient of herbicide, its underlying toxicity on fish is still
unclear. The aim of this study was to evaluate chronic toxicity of Gly on tilapia via …

Background: Acetaminophen (APAP) overdose results in the production of reactive oxygen
species (ROS), induces hepatocyte necrosis, and leads to acute liver failure. Atractylenolide …