Coumarins have received a considerable attention in the last three decades as a lead
structures for the discovery of orally bioavailable non-peptidic antiviral agents. A lot of …

Compounds incorporating the chromene scaffold are largely present in natural products and
display a wide variety of biological activities. Their low toxicity combined to the broad …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

The combination of heterocycles offers a new opportunity to create novel multicyclic
compounds having improved biological activity. Coumarins are ubiquitous natural …

Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …

Viral infections cause many serious human diseases with high mortality rates. New drug‐
resistant strains are continually emerging due to the high viral mutation rate, which makes it …

Naturally occurring coumarins, having wide spectrum of activities such as antioxidant, anti-
inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the …

Tuberculosis (TB) is still a challenging worldwide health problem and mycobacterium
tuberculosis (MTB) remains one of the most deadly human pathogens. TB is the second …

Abstract Machine learning is a well-known approach for virtual screening. Recently, deep
learning, a machine learning algorithm in artificial neural networks, has been applied to the …

Epstein–Barr virus (EBV) is a human γ-herpesvirus that infects up to 95% of the adult
population. Primary EBV infection usually occurs during childhood and is generally …