Genome and metagenome comparisons based on large amounts of next-generation
sequencing (NGS) data pose significant challenges for alignment-based approaches due to …

Modern microbial taxonomy generally relies on the use of single marker genes or sets of
concatenated genes to generate a framework for the delineation and classification of …

Metagenomic sequencing has greatly enhanced the discovery of viral genomic sequences;
however, it remains challenging to identify the host (s) of these new viruses. We developed …

Variable number tandem repeats (VNTRs) account for significant genetic variation in many
organisms. In humans, VNTRs have been implicated in both Mendelian and complex …

The rise in metagenomics has led to an exponential growth in virus discovery. However, the
majority of these new virus sequences have no assigned host. Current machine learning …

Highlights•Despite being an ecologically diverse and speciose insect order, genomes are
available for< 10 of the 43 Lepidoptera superfamilies.•Genome-scale data are advancing …

We study the number N k of length-k word matches between pairs of evolutionarily related
DNA sequences, as a function of k. We show that the Jukes-Cantor distance between two …

Papillomaviruses have been evolving alongside their hosts for at least 450 million years.
This review will discuss some of the insights gained into the evolution of this diverse family …

Metagenomics is a rapidly expanding field that uses next-generation sequencing technology
to analyze the genetic makeup of environmental samples. However, accurately identifying …

Motivation K-mer-based methods are used ubiquitously in the field of computational biology.
However, determining the optimal value of k for a specific application often remains …