The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

After multiple drugs were removed from the market secondary to drug‐induced torsade de
pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in …

Although drugs are intended to be selective, at least some bind to several physiological
targets, explaining side effects and efficacy. Because many drug–target combinations exist …

Background—The current proarrhythmia safety testing paradigm, although highly efficient in
preventing new torsadogenic drugs from entering the market, has important limitations that …

Targeted therapy is considerably changing the treatment and prognosis of cancer.
Progressive understanding of the molecular mechanisms that regulate the establishment …

Drug-induced torsades de pointes (TdP) arrhythmia is a major safety concern in the process
of drug design and development. The incidence of TdP tends to be low, so early pre-clinical …

Cardiac I Kr is a critical repolarizing current in the heart and a target for inherited and
acquired long-QT syndrome (LQTS). Biochemical and functional studies have demonstrated …

Abstract Background and Objective Domperidone is a drug used globally for relieving
nausea and vomiting and stimulating breast milk production. Several case reports and …

Drug block of the human ether-à-go-go-related gene K+ channel (hERG) is the most
common cause of acquired long QT syndrome, a disorder of cardiac repolarization that may …

Malignant migrating partial seizure of infancy (MMPSI) is a devastating and
pharmacoresistant form of infantile epilepsy. MMPSI has been linked to multiple gain-of …