Osteoarthritis is the most common musculoskeletal disease causing chronic disability in
adults. Studying cartilage aging, chondrocyte senescence, inflammation, and autophagy …

With the aging world population, the prevalence of aging‐related disorders is on the rise.
Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's …

Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying
therapies are not available, novel therapeutic targets need to be discovered and prioritized …

Introduction Osteoarthritis (OA) is a heterogeneous and complex disease. We have used a
network biology approach based on genome-wide analysis of gene expression in OA knee …

Osteoarthritis (OA) is characterized by cartilage destruction, chronic inflammation, and local
pain. Evidence showed that retinoic acid receptor-related orphan receptor-α (RORα) is …

Exposure to artificial light at night (LAN) can induce obesity, depressive disorder and
osteoporosis, but the pernicious effects of excessive LAN exposure on tissue structure are …

Despite acknowledgement in the scientific community of sex-based differences in cartilage
biology, the implications for study design remain unclear, with many studies continuing to …

Summary This Year in Review was derived from a personal selection of articles investigating
biological mechanisms of osteoarthritis (OA) and presented at the OARSI World Congress …

BMAL1 is a core component of the circadian clock loop, which directs the sophisticated
circadian expression of clock-controlled genes. Skeletal Bone development is a complex …

Metabolism is one of the most complex cellular biochemical reactions, providing energy and
substances for basic activities such as cell growth and proliferation. Early studies have …